ROME - Zlatan Ibrahimovic picked up where he left off with two more extraordinary goals for Inter at the Stadio Olimpico.
The Swedish forward, whose sublime backheeled goal saw the Nerazzurri on their way to a 2-1 victory over Bologna before the international break, scored in each half of Sunday evening's Serie A showdown.
Dejan Stankovic and Nsofor Victor Obinna added the others in a spectacular second-half scoring spree as Inter went on to rout Roma 4-0.
The victory puts Inter two points clear of Napoli, Catania and Udinese at the top of the table after seven rounds of matches.
Ibrahimovic silenced the home fans after just five minutes, collecting Cordoba's long pass down the right flank and lobbing Doni from a tight angle.
He added his second two minutes after restart, receiving from Muntari and sliding under the Roma keeper after a surging run on goal.
Dejan Stankovic made the result safe on 54 minutes, half-volleying beyond the despairing Doni for his first goal at club level since his strike against Udinese on the opening day of the 2007/08 season.
Inter weren't done though and within two minutes Obinna opened his scoring account for the Nerazzurri, finding the top right corner with a perfectly executed 20-yard shot.
Maicon almost capped a superlative performance with a fifth goal when he stole in to head Mancini's cross on to the post.
Roma 0-4 Inter (HT: 0-1)
Scorers: Ibrahimovic 5, 47, Stankovic 54, Obinna 56.
Roma: 32 Doni; 3 Cicinho, 15 Loria, 4 Juan, 17 Riise; 16 De Rossi, 8 Aquilani; 11 Taddei (89 Okaka 75), 20 Perrotta (33 Brighi 78), 9 Vucinic; 10 Totti (24 Menez 69).
Subs not used: 25 Arthur, 7 Pizarro, 22 Tonetto, 23 Montella.
Coach: Luciano Spalletti.
Inter: 12 Julio Cesar; 13 Maicon, 2 Cordoba, 26 Chivu, 4 Zanetti; 5 Stankovic (15 Dacourt 78), 19 Cambiasso, 20 Muntari; 21 Obinna, 8 Ibrahimovic (9 Cruz 83), 77 Quaresma (33 Mancini 69).
Subs not used: 1 Toldo, 10 Adriano, 25 Samuel, 45 Balotelli.
Coach: José Mourinho.
Referee: Nicola Rizzoli (Bologna).
Booked: Vucinic 33, Chivu 76.