MILAN - Ivan Ramiro Cordoba and Sulley Muntari got the goals as Inter put the midweek defeat to Panathinaikos behind them with a 2-1 win over Napoli.
Ezequiel Lavezzi pulled one back for the Azzurri but Inter held on for a win that sees the defending champions move six points clear at the top of the table ahead of tonight's match between Palermo and second-place AC Milan.
Mourinho made three changes to the team that lost to Panathinaikos, bringing in Samuel, Stankovic and Cruz for Materazzi, Figo and Adriano.
Inter made a roaring start and were in front in the 16th minute when Cordoba hooked into the far corner after Maicon played his corner short to Muntari.
The Ghana midfielder made it two-nothing with his second in as many league games on 25 minutes finishing off a swift move with a classy backheeled finish from Maicon's cross-shot after the Brazilian was beautifully played in by Julio Cruz.
Argentina international Lavezzi reduced the gap eleven minutes later, bursting past Samuel on the right wing and one-twoing with Zalayeta before lifting over Julio Cesar.
Napoli fought hard for an equaliser after the interval but the best chances of a second-half goal were black and blue, with Ibrahimovic having a blistering shot blocked by Iezzo who later denied a goal-bound Zanetti.
Chilean midfielder Luis Jimenez replaced Muntari in the closing minutes to mark his return to action after a lengthy spell on the sidelines.
Inter 2-1 Napoli (HT: 2-1)
Scorers: Cordoba 16, Muntari 25, Lavezzi 36.
Inter: 12 Julio Cesar; 13 Maicon, 2 Cordoba, 25 Samuel, 6 Maxwell; 4 Zanetti, 19 Cambiasso, 20 Muntari (11 Jimenez 90); 5 Stankovic (16 Burdisso 84); 8 Ibrahimovic, 9 Cruz (10 Adriano 72).
Subs not used: 22 Orlandoni, 7 Figo, 18 Crespo, 33 Mancini.
Coach: José Mourinho.
Napoli: 1 Iezzo; 83 Rinaudo, 28 Cannavaro, 6 Aronica; 11 Maggio (9 Denis 79), 5 Pazienza (18 Bogliacino 84), 23 Gargano, 17 Hamsik (8 Blasi 66), 77 Mannini; 25 Zalayeta, 7 Lavezzi.
Subs not used: 30 Navarro, 3 Vitale, 4 Montervino, 13 Santacroce.
Coach: Edoardo Reja.
Referee: Roberto Rosetti (Turin).
Booked: Aronica 50, Zanetti 50, Rinaudo 63, Lavezzi 80.