MONTE CARLO - A counter-attacking Colchoneros side got the better of Inter at the Stade Louis II to lift the 2010 UEFA Super Cup.
José Antonio Reyes and Sergio Aguero got their names on the scoresheet in the second half as Atletico made their chances count in European football's curtain raiser.
With time running out Diego Milito had a penalty kick saved by David De Gea.
Rafael Benitez made one change from the starting XI that won us the Champions League and the Italian Super Cup, bringing in Dejan Stankovic for Goran Pandev.
Quique Sanchez Flores also made a single switch from the team that beat Fulham to win the inaugural Europa League, summer signing Diego Godin replacing Antonio Lopez at the centre of defence.
An evenly-balanced first half saw Samuel head over and Eto'o fire narrowly wide before two good chances for Aguero - one inches off target and the other well wide.
It was more Spain than Italy in the second half as Atletico found more space on the break, and Reyes broke the deadlock on 62 minutes. He combined swiftly with Aguero and rounded Maicon before firing past Julio Cesar at his near post.
Inter reverted to their Champions League-winning lineup with Pandev on for Stankovic and the Macedonian fired against the bar after De Gea had thwarted Milito, but the flag had already been raised for offside.
Another change was needed and Benitez handed brought on Coutinho for Sneijder.
The 18-year-old Brazilian barely had time to settle on his competitive debut when Aguero doubled Atletico's lead from close range, slotting Simao's cross over the line.
Inter were presented with a chance to reduce the arrears in the closing minutes after Raul Garcia brought down Pandev in the area, but Milito's spot-kick was saved by De Gea.
Inter 0-2 Atletico Madrid (HT: 0-0)
Scorers: Reyes 62, Aguero 83.
Inter: 1 Julio Cesar; 13 Maicon, 6 Lucio, 25 Samuel, 26 Chivu; 5 Stankovic (27 Pandev 68), 19 Cambiasso, 4 Zanetti; 10 Sneijder (29 Coutinho 79), 9 Eto'o; 22 Milito.
Subs not used: 12 Castellazzi, 2 Cordoba, 17 Mariga, 23 Materazzi, 88 Biabiany.
Coach: Rafael Benitez.
Atletico Madrid: 13 De Gea; 17 Ujfalusi, 15 Godin, 21 Perea, 18 Dominguez; 19 Reyes (11 Merida 69), 12 Assuncao, 8 Raul Garcia, 20 Simao (6 Camacho 90+2); 7 Forlan (9 Jurado 82), 10 Aguero.
Subs not used: 38 Robles, 3 A.Lopez, 4 Suarez, 22 Diego Costa.
Coach: Quique Sanchez Flores.
Referee: Massimo Busacca (Switzerland).
Booked: Simao 85, Raul Garcia 89, Samuel 90+2.